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Welcome to RANZCR
Trans-Tasman Radiation Oncology Group Inc (TROG)
Trans-Tasman Radiation Oncology Group Inc (TROG)
Welcome to RANZCR
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Welcome to RANZCR
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Welcome to RANZCR
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Welcome to RANZCR
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TROG Clinical Trials
                 

A list of all TROG trials (open, closed, approved for activation, approved for further development) follows:

Open Trials
Click on the individual trial no. for Further Information, ie. trial contact details, target accrual, aims.

Trial No. Trial Title
TROG 99.03 A Randomised Multicentre Trial Of Involved Field Radiotherapy Versus Involved Field Radiotherapy Plus Chemotherapy in combination with Rituximab (MabThera®) For Stage I – II Low Grade Follicular Lymphoma.
TROG 99.04 A prospective, non-randomised study of chemotherapy and radiotherapy for Osteolymphoma (OL).
TROG 99.05 Tumour volume as an independent prognostic factor in patients with non-small cell lung cancer: A protocol for a prospective database.
TROG 02.01 Randomised clinical trial of surgery versus surgery plus adjuvant radiotherapy for regional control in patients with completely resected macroscopic nodal metastatic melanoma.
TROG 02.03 Multicentre phase III study comparing radical synchronous chemo-radiation vs radical radiation alone in the definitive management of muscle invasive TCC of the urinary bladder following maximal TUR.
TROG 03.01 A randomised phase III study in advanced oesophageal carcinoma to compare dysphagia in patients treated with radiotherapy versus chemo-radiotherapy.
TROG 03.03 An ALLG/TROG Prospective Multicentre Study of Involved-Field Radiotherapy with Transplantation for Patients with Hodgkin's disease and non-Hodgkin's lymphoma.
TROG 03.04 Randomised trial investigating the effect on survival and PSA control of different durations of adjuvant androgen deprivation in association with definitive radiation treatment for localised carcinoma of the prostate (RADAR).
TROG 03.06 A collaborative randomised phase III trial: The timing of intervention with androgen deprivation in prostate cancer patients with a rising PSA.
TROG 03.07 A Randomised Phase II Study of Two Regimens of Palliative Chemoradiation Therapy in the Management of Locally Advanced Non Small Cell Lung Cancer.
TROG 03.08 A randomised trial of re-irradiation dose for bony metastases (NCIC SC.20).
TROG 04.01 A paired randomised comparison of Cavilon Durable Barrier Cream to 10% Glycerine ("Sorbolene) in the prophylactic management of post-mastectomy irradiation skin care.
TROG 04.02 Prospective study to determine the relationships between survival and FIGO stage, tumour volume and corpus invasion in cervical cancer.
TROG 05.01 Post-operative concurrent chemo-radiotherapy versus post-operative radiotherapy in high-risk cutaneous squamous cell carcinoma of the head and neck.
TROG 05.02 A prospective single arm trial of involved field radiotherapy alone for stage I-II low grade non-gastric marginal zone lymphoma.
TROG 06.01 Primary chemotherapy with Temozolomide vs radiotherapy in patients with low grade gliomas after stratification for genetic 1p loss: a phase III study. (EORTC 22033-26033)

Closed Trials

Trial No. Trial Title
TROG 03.05 A phase III study of regional RT in early breast cancer (NCIC MA20).
TROG 03.02 A feasibility study to evaluate adjuvant chemo-radiotherapy for gastric cancer.
TROG 02.02 A phase III randomised trial of concomitant radiation, cisplatin, and tirapazamine vs concomitant radiation and cisplatin in patients with advanced head and neck cancer.
TROG 01.05 A pilot randomised controlled trial of dexamethasone 96mg versus 16mg per day for malignant spinal cord compression treated by radiotherapy – TROG Superdex Pilot.
TROG 01.04 A randomised trial of preoperative radiotherapy for stage T3 adenocarcinoma of rectum.
TROG 01.03 Concomitant and adjuvant temozolomide and radiotherapy for newly diagnosed glioblastoma multiforme (EORTC 26981/22981).
TROG 01.02 A phase II study of idarubicin based combined modality therapy in primary central nervous system lymphoma.
TROG 01.01 A phase III double-blind, randomised, placebo-controlled study of erythropoietin when used as an adjuvant to radiation therapy in patients with head and neck squamous cell carcinoma (EORTC 22996).
TROG 99.06 Phase I/II study of trans-urethral resection followed by modified synchronous chemo-radiation in the definitive management of localised invasive TCC of the urinary bladder.
TROG 99.02 A prospective single arm non randomised study of concurrent radiation and chemotherapy for the organ conserving treatment of early anal canal cancer.
TROG 99.01 An ANZLG / TROG Prospective study of limited chemotherapy and involved field radiotherapy for patients with clinical stage I – II Hodgkins Disease.
TROG 98.06 Concurrent radiotherapy and chemotherapy for oesophageal cancer patients.
TROG 98.05 A randomised trial of whole brain irradiation following local treatment of solitary brain metastases.
TROG 98.04 A phase II study examining the efficacy of short fractionation radiotherapy for the palliation of liver metastases.
TROG 98.03 A randomised trial to compare rates of disease-free survival in margin-positive patients after radical prostatectomy for carcinoma of the prostate with or without adjuvant post-operative radiotherapy.
TROG 98.02 A randomised phase II study of two different strategies for chemoradiotherapy of advanced squamous cell carcinoma of the head and neck.
TROG 98.01 A Phase II trial of preoperative radiotherapy with protracted infusion 5-fluorouracil for resectable adenocarcinoma of rectum.
TROG 97.01 A Phase II study of trans-urethral resection followed by synchronous chemo-radiation in the definitive treatment of localised TCC of the urinary bladder.
TROG 96.07 A Phase II study of synchronous carboplatin/etopside and radiation in Merkel cell carcinoma of the skin.
TROG 96.06 A Phase II study of radiation therapy following nodal surgery in malignant melanoma.
TROG 96.05 A prospective randomised trial of single fraction versus fractionated radiotherapy for neuropathic pain due to bone metastases.

TROG 96.04

Phase III comparison of radiotherapy with glucocorticoid steroid support for the palliation of liver metastases

TROG 96.03

Concomitant accelerated radiotherapy boost for good prognosis oesophageal patients
TROG 96.02 Standard radio-chemotherapy for oesophageal cancer patients.
TROG 96.01 A randomised trial investigating the effectiveness of different durations of maximal androgen deprivation prior to and during definitive radiation therapy for locally advanced carcinoma of the prostate.
TROG 95.03 Phase III double blind study of pentosan polysulphate sodium (PPS) in the treatment of late (chronic) radiation proctitis.
TROG 95.02 A phase III double-blind randomised trial of rectal sucralfate suspension in the treatment of radiation proctitis.

TROG 95.01

A randomised trial comparing adjuvant protracted venous infusion and bolus 5FU/Leucovorin with either early or late radiotherapy in rectal Cancer
TROG 94.01 A randomised phase III trial comparing surgery alone with concurrent preoperative radiation and chemotherapy followed by surgery for localised resectable carcinoma of the oesophagus.
TROG 92.01 A phase II study of intravenous methotrexate and cranial irradiation in the treatment of primary central nervous system lymphoma (PCNSL).
TROG 91.01 Phase III accelerated head and neck trial.
TROG 89.04 Synchronous radiotherapy and chemotherapy in oesophageal cancer.
TROG 89.03 Phase II study of accelerated fractionation radiotherapy for stage III squamous carcinoma of the upper aero-digestive tract.
TROG 89.02 Simultaneous adjuvant radiation and CMF chemotherapy following surgery for breast cancer.

Trials Approved for Activation

Trial No.
Trial Title
TROG 07.01 A phase III study of radiation dose escalation and fractionation in women with non-low risk ductal carcinoma in situ (DCIS) of the breast
TROG 06.02 A multicentre feasibility study of three-dimensional conformal radiation therapy for accelerated partial breast irradiation

Trials Approved for Further Development

Click on the individual trial for Trial Chair contact details:

Trial Title
Phase III study comparing post-operative radiotherapy to no post-operative radiotherapy in patients with histologically proven mediastinal involvement and completely resected non small cell lung cancer (LUNG ART- Lung Adjuvant Radiotherapy Trial)
SUPREMO (Selective Use of Postoperative Radiotherapy aftEr MastectOmy) BIG 2-04 (ANZBCTG)
QUARTZ – Quality of life After RadioTherapy and/or Steroids (previously called OSCAR)
A randomised comparison of anastrozole commenced before and continued during radiotherapy for breast cancer versus anastrozole and subsequent anti-oestrogen therapy delayed until after radiotherapy.(Brief name: TROG STARS Breast trial)
A multicentre trial of the use of Sentinel Lymph Node Biopsy (SLNB) to determine the Radiotherapy (RT) volumes for treatment of cN0-1 Squamous Cell Cancer (SCC) of the anus
Whole Brain Radiotherapy following local treatment of intracranial metastases of melanoma – a randomised phase III trial
A Phase II study of cetuximab, carboplatin and concomitant boost radiotherapy for locally advanced Head and Neck Squamous Cell Carcinoma
Radiotherapy with Humidification in head and neck cancer
Hypofractionated radiation and concurrent Temozolomide chemotherapy in patients with newly-diagnosed glioblastoma multiforme unsuitable for conventionally-fractionated radiotherapy
Phase II study of zoledronic acid followed by delayed palliative radiotherapy (if necessary) in patients with painful bone metastases (from non-breast, non-prostate solid tumour malignancies)
RAVES: Radiotherapy – Adjuvant Versus Early Salvage

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