If you are interested in participating in the following trial, please contact the relevant Trial Chairperson or Trial Centre Data Manager.

TROG 03.08 - A randomised trial of re-irradiation dose for bony metastases (NCIC SC.20)

Date first patient entered: 3 March 2004

Target Accrual: 650 (internationally)

Aim: To compare pain relief after re-irradiation of symptomatic bone metastases with 8 Gy or 20 Gy
Secondary Objectives:
To determine the overall incidence of pain relief in patients undergoing re-irradiation for symptomatic bone metastases;
To determine the time to pain progression after re-irradiation;
To assess the relationship between response to initial radiation and pain relief with re-irradiation;
To determine the changes in functional interference following re-irradiation using the Brief Pain Inventory (and QoL using EORTC QLQ C30 in Canada and the Netherlands);
To determine the characteristics of the group of non-responders (to both the initial and re irradiation);
To monitor the incidence of acute severe radiation related side effects;
To monitor the incidence of in-field pathological fractures and spinal cord compression.

Trial Contacts:
TROG Trial Chairperson
Assoc Prof Daniel Roos
Royal Adelaide Hospital
North Terrace
Adelaide SA 5000
Fax: +61 8 8222 2016

Trial Centre Data Manager
Julie Butters
Royal Adelaide Hospital
North Terrace
Adelaide SA 5000
Fax: +61 8 8222 2016

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